Josephine Morrow is Girl One, the first of nine "Miracle Babies" conceived without male DNA, raised on an experimental commune known as the Homestead. When a suspicious fire destroys the commune and claims the lives of two of the Homesteaders, the remaining Girls and their Mothers scatter across the United States and lose touch. Years later, Margaret Morrow goes missing, and Josie sets off on a desperate road trip, tracking down her estranged sisters who seem to hold the keys to her mother's disappearance. Tracing the clues Margaret left behind, Josie joins forces with the other Girls, facing down those who seek to eradicate their very existence while uncovering secrets about their origins and unlocking devastating abilities they never knew they had.