As she settles into motherhood and a happy marriage, Lindsay Boxer thinks she has found domestic bliss. But when a beautiful, alluring blonde woman with links to the CIA disappears from the scene of a brutal murder at a downtown luxury hotel, Lindsay's life begins to unravel. Before she can track down the woman for questioning, a plane crash plunges San Francisco into chaos and Lindsay's husband Joe vanishes. The deeper she digs, the more Lindsay suspects that Joe shares a secret past with the mystery blonde. Thrown into a tailspin and questioning everything she thought she knew, Lindsay turns to the Women's Murder Club for help as she tries to uncover the truth.