Details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor mistakenly artificially inseminates her during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.