When researchers discover a fossil of the Mythical Pokémon Mew, they bring upon themselves a creation that goes against the very laws of nature: Mewtwo, a Legendary Pokémon intended for use as a tool of destruction. But as Mewtwo becomes aware of its existence, it begins to resent its human creators and seeks revenge--and Ash, Pikachu and their friends find themselves at the center of its rampage! With the future of the Pokémon world at stake, will our heroes be able to overcome Mewtwo's challenge...and will Mewtwo be able to find a new meaning for its life?