The seventh season finds Pride and the team fighting for justice in their beloved city as New Orleans grapples with the effects of COVID-19. Pride, seeing how the pandemic has overwhelmed the system, finds creative ways to help his neighbors with the assistance of Rita Devereaux, and is asked by the Mayor to be a part of a special task force assigned to help make actual change in their city. Also, Wade is overwhelmed by the high volume in the morgue due to COVID-19, Hannah shoulders being separated from her daughter, and Tammy and Carter investigate a suspicious death aboard a humanitarian ship offshore, where they learn that some crew members are infected with the deadly virus.