Spider-Woman is back, and she's pulling no punches! But Jessica Drew hasn't been feeling like herself lately. When the angry, irritable, and unwell Spider-Woman takes a simple security gig to help get back on her feet, she finds herself suddenly besieged by unknown forces out to destroy everything around her. What's wrong with Jessica? Just how did she get this job? Who are these violent lunatics who keep trying to blow her up? What does her illness have to do with the daughter of her old nemesis Otto Vermis? And how does a shipment of black-market spiders fit in? Jessica Drew is fighting for her life while someone pulls her strings, in an explosive new adventure that takes Spider-Woman to new heights!